Molecule Details
| InChIKey | QOYHHIBFXOOADH-UHFFFAOYSA-N |
|---|---|
| Compound Name | Fluspirilene |
| Canonical SMILES | O=C1NCN(c2ccccc2)C12CCN(CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 16 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.11 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB04842 |
|---|---|
| Drug Name | Fluspirilene |
| CAS Number | 1841-19-6 |
| Groups | approved withdrawn |
| ATC Codes | N05AG01 |
| Description | A long-acting injectable antipsychotic agent used for chronic schizophrenia. |
Categories: Agents causing hyperkalemia Antiarrhythmic agents Antidepressive Agents Antipsychotic Agents Bradycardia-Causing Agents Calcium Channel Blockers Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Diphenylbutylpiperidine Derivatives Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Imidazoles Moderate Risk QTc-Prolonging Agents Nervous System Neurotoxic agents Neurotransmitter Agents Piperidines Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Spiro Compounds Tranquilizing Agents
Cross-references: BindingDB: 26948 ChEBI: 93369 CHEMBL46516 ChemSpider: 3279 Drugs Product Database (DPD): 2260 Guide to Pharmacology: 85 IUPHAR: 85 D02629 PharmGKB: PA162565878 PubChem:3396 PubChem:46508202 RxCUI: 4507 Therapeutic Targets Database: DAP000980 Wikipedia: Fluspirilene ZINC: ZINC000000537755
Target Activities (16)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P14416 | DRD2 | Homo sapiens | Human | PF00001 | 9.4 | Ki | BindingDB |
| P35462 | DRD3 | Homo sapiens | Human | PF00001 | 8.4 | Ki | BindingDB |
| P21917 | DRD4 | Homo sapiens | Human | PF00001 | 8.3 | Ki | BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 8.0 | Ki | BindingDB |
| P35367 | HRH1 | Homo sapiens | Human | PF00001 | 7.9 | Ki | BindingDB |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 7.3 | Ki | BindingDB |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 7.2 | Ki | BindingDB |
| P18825 | ADRA2C | Homo sapiens | Human | PF00001 | 7.2 | Ki | BindingDB |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL;BindingDB |
| P41146 | OPRL1 | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL;BindingDB |
| P07550 | ADRB2 | Homo sapiens | Human | PF00001 | 6.3 | Ki | BindingDB |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P08588 | ADRB1 | Homo sapiens | Human | PF00001 | 6.2 | Ki | BindingDB |
| P20366 | TAC1 | Homo sapiens | Human | PF02202 | 6.0 | Ki | BindingDB |
| P21731 | TBXA2R | Homo sapiens | Human | PF00001 | 6.0 | Ki | BindingDB |
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 6.0 | Ki | BindingDB |