Molecule Details
| InChIKey | QOIGKGMMAGJZNZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Gepirone |
| Canonical SMILES | CC1(C)CC(=O)N(CCCCN2CCN(c3ncccn3)CC2)C(=O)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.37 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB12184 |
|---|---|
| Drug Name | Gepirone |
| CAS Number | 83928-76-1 |
| Groups | approved |
| ATC Codes | N06AX19 |
| Description | Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release tablet necessitates frequent administration... |
Categories: Anti-Anxiety Agents Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Nervous System Neurotransmitter Agents Psychoanaleptics Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Receptor Agonists Tranquilizing Agents
Cross-references: BindingDB: 50005132 ChEBI: 135990 CHEMBL284092 ChemSpider: 49836 PubChem:55191 PubChem:347828470 RxCUI: 2672253 Wikipedia: Gepirone ZINC: ZINC000002021499