Molecule Details
InChIKeyQNUKRWAIZMBVCU-WCIBSUBMSA-N
Compound NameSU 9516
Canonical SMILESCOc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)17
Pfam Stratification Cross-Family
Avg pChEMBL7.04
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB03428
Drug NameSU9516
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Categories: Heterocyclic Compounds, Fused-Ring
Cross-references: BindingDB: 50503353 CHEMBL258805 ChemSpider: 4451397 PDB: SU9 PubChem:5289419 PubChem:46509014 Therapeutic Targets Database: DNC001389 ZINC: ZINC000014806879
Target Activities (17)
Target Gene Organism Category Pfam pChEMBL Type Source
O95067 CCNB2 Homo sapiens Human PF02984 PF00134 7.7 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 7.7 IC50 ChEMBL;BindingDB
Q8WWL7 CCNB3 Homo sapiens Human PF02984 PF00134 7.7 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 7.6 IC50 ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 7.6 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 7.5 pIC50 TTD_MultiTarget
P11802 CDK4 Homo sapiens Human PF00069 7.5 pIC50 TTD_MultiTarget
Q00535 CDK5 Homo sapiens Human PF00069 7.4 IC50 ChEMBL
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 7.2 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 IC50 ChEMBL
Q86UE8 TLK2 Homo sapiens Human PF00069 6.5 IC50 ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.5 IC50 ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.5 IC50 ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.0 IC50 ChEMBL;BindingDB
P51948 MNAT1 Homo sapiens Human PF25811 PF06391 PF17121 6.0 IC50 ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P06493 CDK1 Cyclin-dependent kinase 1 binder targets
P24941 CDK2 Cyclin-dependent kinase 2 inhibitor targets
Q00535 CDK5 Cyclin-dependent kinase 5 inhibitor targets