Molecule Details
InChIKeyQNUKRWAIZMBVCU-UHFFFAOYSA-N
Compound Name3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
Canonical SMILESCOc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)46
Pfam Stratification Cross-Family
Avg pChEMBL6.56
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (46)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00535 CDK5 Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.6 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.5 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.4 IC50 ChEMBL;BindingDB
P06493 CDK1 Homo sapiens Human PF00069 7.3 IC50 ChEMBL;BindingDB
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.3 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.1 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.1 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.0 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.9 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.9 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.9 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.7 Ki ChEMBL
P11802 CDK4 Homo sapiens Human PF00069 6.6 IC50 BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.5 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 IC50 ChEMBL;BindingDB
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.4 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.4 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.3 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.2 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.2 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.2 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.2 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.1 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.1 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.0 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.0 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.0 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL