Molecule Details
InChIKeyQNDVLZJODHBUFM-WFXQOWMNSA-N
Compound NameOkadaic Acid
Canonical SMILESC=C1[C@@H](O)[C@@H]2O[C@]3(CC[C@H](/C=C/[C@@H](C)[C@@H]4CC(C)=C[C@@]5(O[C@H](C[C@@](C)(O)C(=O)O)CC[C@H]5O)O4)O3)CC[C@H]2O[C@@H]1[C@@H](O)C[C@H](C)[C@H]1O[C@@]2(CCCCO2)CC[C@H]1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL8.21
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB02169
Drug Name9,10-Deepithio-9,10-Didehydroacanthifolicin
CAS Number78111-17-8
Groups experimental
ATC Codes nan
DescriptionA specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)

Cross-references: BindingDB: 50110676 ChEBI: 44658 CHEMBL280487 ChemSpider: 393845 C01945 PDB: OKA PubChem:446512 PubChem:46504468 ZINC: ZINC000085601542
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
Q15172 PPP2R5A Homo sapiens Human PF01603 10.2 IC50 ChEMBL;BindingDB
P18031 PTPN1 Homo sapiens Human PF00102 8.5 IC50 ChEMBL;BindingDB
P48307 TFPI2 Homo sapiens Human PF00014 8.5 IC50 ChEMBL
P67775 PPP2CA Homo sapiens Human PF00149 8.2 IC50 ChEMBL;BindingDB
P50391 NPY4R Homo sapiens Human PF00001 8.0 IC50 ChEMBL
P36873 PPP1CC Homo sapiens Human PF00149 PF16891 7.3 IC50 ChEMBL;BindingDB
O75688 PPM1B Homo sapiens Human PF00481 PF07830 6.9 IC50 ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit binder targets
P28562 DUSP1 Dual specificity protein phosphatase 1 inhibitor targets