Molecule Details
InChIKeyQNABDSWBQJKBHK-UHFFFAOYSA-N
Compound Name4-[6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide
Canonical SMILESO=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)45
Pfam Stratification Cross-Family
Avg pChEMBL7.02
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (45)
Target Gene Organism Category Pfam pChEMBL Type Source
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 9.0 IC50 ChEMBL;BindingDB
P24941 CDK2 Homo sapiens Human PF00069 7.9 IC50 ChEMBL;BindingDB
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 7.9 IC50 ChEMBL;BindingDB
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 7.8 IC50 ChEMBL;BindingDB
O60285 NUAK1 Homo sapiens Human PF00069 7.8 IC50 ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.7 IC50 ChEMBL;BindingDB
Q00535 CDK5 Homo sapiens Human PF00069 7.7 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 7.7 IC50 ChEMBL;BindingDB
P29322 EPHA8 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 7.7 IC50 ChEMBL;BindingDB
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.6 IC50 ChEMBL;BindingDB
O00141 SGK1 Homo sapiens Human PF00069 PF00433 7.6 IC50 ChEMBL;BindingDB
P08631 HCK Homo sapiens Human PF07714 PF00017 PF00018 7.5 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 7.5 IC50 ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 7.5 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 7.4 IC50 ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.4 IC50 ChEMBL;BindingDB
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 7.3 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 7.3 IC50 ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 7.2 IC50 ChEMBL;BindingDB
P21802 FGFR2 Homo sapiens Human PF07679 PF13927 PF07714 7.2 IC50 ChEMBL;BindingDB
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.1 IC50 ChEMBL;BindingDB
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 7.1 IC50 ChEMBL;BindingDB
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.9 IC50 ChEMBL;BindingDB
P51957 NEK4 Homo sapiens Human PF00069 6.8 IC50 ChEMBL;BindingDB
P29320 EPHA3 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF07647 6.7 IC50 ChEMBL;BindingDB
P36896 ACVR1B Homo sapiens Human PF01064 PF00069 PF08515 6.7 IC50 ChEMBL;BindingDB
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.7 IC50 ChEMBL;BindingDB
P49841 GSK3B Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
P48729 CSNK1A1 Homo sapiens Human PF00069 6.6 IC50 ChEMBL;BindingDB
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.6 IC50 ChEMBL;BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 IC50 ChEMBL;BindingDB
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.5 IC50 ChEMBL;BindingDB
P49840 GSK3A Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.4 IC50 ChEMBL;BindingDB
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.4 IC50 ChEMBL;BindingDB
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 6.4 IC50 ChEMBL;BindingDB
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.4 IC50 ChEMBL;BindingDB
P43405 SYK Homo sapiens Human PF07714 PF00017 6.4 IC50 ChEMBL;BindingDB
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.3 IC50 ChEMBL;BindingDB
P15056 BRAF Homo sapiens Human PF00130 PF07714 PF02196 6.3 IC50 ChEMBL;BindingDB
P11309 PIM1 Homo sapiens Human PF00069 6.2 IC50 ChEMBL;BindingDB
P25098 GRK2 Homo sapiens Human PF00169 PF00069 PF00615 6.2 IC50 ChEMBL;BindingDB
P04049 RAF1 Homo sapiens Human PF00130 PF07714 PF02196 6.2 IC50 ChEMBL;BindingDB
P45984 MAPK9 Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB