Molecule Details
| InChIKey | QMUKOEKTUBVPFU-DVZOWYKESA-N |
|---|---|
| Compound Name | N-[3-[[(4Z)-4-(1,3-benzothiazol-6-ylmethylidene)-5-oxoimidazolidin-2-ylidene]amino]-1-adamantyl]acetamide |
| Canonical SMILES | CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 12 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.42 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (12)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q13627 | DYRK1A | Homo sapiens | Human | PF00069 | 9.0 | IC50 | ChEMBL |
| Q9HAZ1 | CLK4 | Homo sapiens | Human | PF00069 | 8.7 | IC50 | ChEMBL |
| P49760 | CLK2 | Homo sapiens | Human | PF00069 | 8.5 | IC50 | ChEMBL |
| Q9Y463 | DYRK1B | Homo sapiens | Human | PF00069 | 8.4 | IC50 | ChEMBL |
| P49759 | CLK1 | Homo sapiens | Human | PF00069 | 8.2 | IC50 | ChEMBL |
| O43781 | DYRK3 | Homo sapiens | Human | PF00069 | 7.7 | IC50 | ChEMBL |
| Q92630 | DYRK2 | Homo sapiens | Human | PF00069 | 7.2 | IC50 | ChEMBL |
| Q9NR20 | DYRK4 | Homo sapiens | Human | PF00069 | 6.6 | IC50 | ChEMBL |
| P49761 | CLK3 | Homo sapiens | Human | PF00069 | 6.2 | IC50 | ChEMBL |
| Q00535 | CDK5 | Homo sapiens | Human | PF00069 | 6.2 | IC50 | ChEMBL |
| Q15078 | CDK5R1 | Homo sapiens | Human | PF03261 | 6.2 | IC50 | ChEMBL |
| P49841 | GSK3B | Homo sapiens | Human | PF00069 | 6.2 | IC50 | ChEMBL |