Molecule Details
InChIKeyQLRRJMOBVVGXEJ-XHSDSOJGSA-N
Canonical SMILESNC(=O)[C@H]1CCN(c2ncnc(N)c2F)C[C@@H]1N1CCC[C@@H](Nc2cc(Cl)cc(C(F)(F)F)c2)C1=O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL8.41
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB16657
Drug NameVecabrutinib
CAS Number1510829-06-7
Groups investigational
ATC Codes nan
DescriptionVecabrutinib is under investigation in clinical trial NCT03037645 (Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers).

Categories: Amines
Cross-references: CHEMBL4297640 ChemSpider: 64835225
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 8.4 IC50 ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 8.4 IC50 ChEMBL
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q06187 BTK Tyrosine-protein kinase BTK inhibitor targets