Molecule Details
InChIKeyQLPWFQPHRAFDGC-UHFFFAOYSA-N
Compound Name3-[3-[5-Methyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-3,9-diazabicyclo[3.3.1]nonan-9-yl]propanenitrile
Canonical SMILESCc1cnc(Nc2cnn(C)c2)nc1N1CC2CCCC(C1)N2CCC#N
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL7.79
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P23458 JAK1 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.7 IC50 ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.5 IC50 ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.5 IC50 ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 8.0 IC50 ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.7 IC50 ChEMBL
P40763 STAT3 Homo sapiens Human PF00017 PF01017 PF02864 PF02865 PF21354 7.2 IC50 ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.0 IC50 ChEMBL