InChIKey	QKDRXGFQVGOQKS-CRSSMBPESA-N
Canonical SMILES	CCOc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.14
Source	ChEMBL;BindingDB

DrugBank ID	DB12713
Drug Name	Sotagliflozin
CAS Number	1018899-04-1
Groups	approved investigational
ATC Codes	A10BK06
Description	Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m<sup>2</sup>.[L39705] Its potency in inhibiting SGLT2...

---

Categories: Alimentary Tract and Metabolism BCRP/ABCG2 Inhibitors Blood Glucose Lowering Agents Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diuretics Drugs Used in Diabetes OATP1B1/SLCO1B1 Inhibitors OATP1B3 inhibitors P-glycoprotein inhibitors Sodium-Glucose Transporter 1, antagonists & inhibitors Sodium-Glucose Transporter 2 Inhibitors Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors UGT1A1 Substrates UGT1A9 Substrates UGT2B7 substrates

---

Cross-references: BindingDB: 50235017 CHEMBL3039507 ChemSpider: 27289071 PDB: LFL PubChem:24831714 PubChem:347828911 RxCUI: 2638675 Wikipedia: Sotagliflozin ZINC: ZINC000095641922