Molecule Details
| InChIKey | QHWJXFZLSVHSGH-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-[7-chloro-3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3,5-dichloro-4-pyridinyl)-2-oxoacetamide |
| Canonical SMILES | N#Cc1ccc(Cc2cc(C(=O)C(=O)Nc3c(Cl)cncc3Cl)c3cc(Cl)ccn23)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.09 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 7.1 | IC50 | ChEMBL |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 7.1 | IC50 | ChEMBL |
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 7.1 | IC50 | ChEMBL |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 7.1 | IC50 | ChEMBL |