Molecule Details
| InChIKey | QFXKXRXFBRLLPQ-UHFFFAOYSA-N |
|---|---|
| Compound Name | Diphenyleneiodonium |
| Canonical SMILES | c1ccc2c(c1)[I+]c1ccccc1-2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.09 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB17025 |
|---|---|
| Drug Name | Diphenyleneiodonium |
| CAS Number | 244-54-2 |
| Groups | experimental |
| ATC Codes | nan |
| Description | An NADPH oxidase 2 (NOX2) inhibitor.[A252987] |
Categories: Blood Glucose Lowering Agents Enzyme Inhibitors Nitric Oxide Synthase, antagonists & inhibitors
Cross-references: BindingDB: 50206334 ChEBI: 77986 CHEMBL365739 ChemSpider: 2990 ZINC: ZINC000100014654
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q96PH1 | NOX5 | Homo sapiens | Human | PF13202 PF13405 PF08022 PF01794 PF08030 | 7.7 | IC50 | ChEMBL |
| Q9NPH5 | NOX4 | Homo sapiens | Human | PF08022 PF01794 PF08030 | 7.0 | IC50 | ChEMBL |
| P04839 | CYBB | Homo sapiens | Human | PF08022 PF01794 PF08030 | 7.0 | IC50 | ChEMBL |
| Q9Y5S8 | NOX1 | Homo sapiens | Human | PF08022 PF01794 PF08030 | 6.6 | IC50 | ChEMBL |