InChIKey	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Compound Name	Sirolimus
Canonical SMILES	CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	9
Pfam Stratification	Cross-Family
Avg pChEMBL	9.07
Source	ChEMBL;BindingDB

DrugBank ID	DB00877
Drug Name	Sirolimus
CAS Number	53123-88-9
Groups	approved investigational
ATC Codes	L01EG04 S01XA23 L04AH01
Description	Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island).[A242412] It was first isolated and identified as an antifungal agent with potent anticandid...

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Categories: Agents causing angioedema Anti-Bacterial Agents Anti-Infective Agents Antibiotics, Antineoplastic Antifungal Agents Antineoplastic and Immunomodulating Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Decreased Immunologic Activity Hyperglycemia-Associated Agents Immunologic Factors Immunosuppressive Agents Immunotherapy Kinase Inhibitor Lactones Macrolides Mammalian target of rapamycin (mTOR) kinase inhibitors Myelosuppressive Agents Narrow Therapeutic Index Drugs OATP1B1/SLCO1B1 Inhibitors Ophthalmologicals P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Polyketides Protein Kinase Inhibitors Selective Immunosuppressants Sensory Organs Sirolimus and Prodrugs mTOR Inhibitor Immunosuppressant mTOR Inhibitors

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Cross-references: BindingDB: 50064359 ChEBI: 9168 CHEMBL413 ChemSpider: 10482078 Drugs Product Database (DPD): 12064 C07909 D00753 PDB: RAP PharmGKB: PA451365 PubChem:5284616 PubChem:46505675 RxCUI: 35302 Therapeutic Targets Database: DNC001197 Wikipedia: Sirolimus ZINC: ZINC000169289388