Molecule Details
| InChIKey | QEVGJXHJXPXEJA-UHFFFAOYSA-N |
|---|---|
| Compound Name | 7-(4-aminocyclohexyl)-N-(2-cyclopropylethyl)-5-(4-fluorophenyl)pyrrolo[2,3-d]pyrimidin-2-amine |
| Canonical SMILES | NC1CCC(n2cc(-c3ccc(F)cc3)c3cnc(NCCC4CC4)nc32)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.16 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 9.1 | IC50 | ChEMBL;BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 9.0 | IC50 | ChEMBL;BindingDB |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 7.5 | IC50 | ChEMBL;BindingDB |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 7.0 | IC50 | ChEMBL;BindingDB |