(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-pyridin-3-ylpyrrolidine-2-carboxamide

InChIKey	`QDVKRHSEGADNGG-SFHVURJKSA-N`
Compound Name	(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-pyridin-3-ylpyrrolidine-2-carboxamide
Canonical SMILES	`O=C(Nc1cccnc1)[C@@H]1CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	6.6
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P08069	IGF1R	Homo sapiens	Human	PF00757 PF07714 PF01030	8.1	IC50	ChEMBL;BindingDB
O96020	CCNE2	Homo sapiens	Human	PF02984 PF00134	6.2	IC50	ChEMBL
P06729	CD2	Homo sapiens	Human	PF05790 PF07686	6.2	pIC50	TTD_MultiTarget
P24864	CCNE1	Homo sapiens	Human	PF02984 PF00134	6.2	IC50	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	6.2	pIC50	TTD_MultiTarget