Molecule Details
InChIKeyQCOULMVHIHJKFY-UHFFFAOYSA-N
Compound Name5-bromo-4-N-(5-methyl-1,3-thiazol-2-yl)-2-N-propan-2-ylpyrimidine-2,4-diamine
Canonical SMILESCc1cnc(Nc2nc(NC(C)C)ncc2Br)s1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)14
Pfam Stratification Cross-Family
Avg pChEMBL6.5
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (14)
Target Gene Organism Category Pfam pChEMBL Type Source
Q00535 CDK5 Homo sapiens Human PF00069 7.6 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.7 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.3 Ki ChEMBL
P29376 LTK Homo sapiens Human PF12810 PF07714 6.3 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 6.3 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q07912 TNK2 Homo sapiens Human PF09027 PF11555 PF07714 PF22931 PF14604 6.1 Ki ChEMBL