Molecule Details
| InChIKey | QAMUWRFOZKONDU-UHFFFAOYSA-N |
|---|---|
| Compound Name | N-(4-chloro-2-methyl-3-pyridinyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Canonical SMILES | Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(N2CCN(CCO)CC2)n1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 7 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.87 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (7)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P00519 | ABL1 | Homo sapiens | Human | PF08919 PF07714 PF00017 PF00018 | 8.8 | IC50 | BindingDB |
| P12931 | SRC | Homo sapiens | Human | PF07714 PF00017 PF00018 | 8.8 | IC50 | BindingDB |
| P14867 | GABRA1 | Homo sapiens | Human | PF02931 PF02932 | 8.8 | IC50 | BindingDB |
| P57059 | SIK1 | Homo sapiens | Human | PF00069 PF23312 | 7.5 | IC50 | BindingDB |
| P10721 | KIT | Homo sapiens | Human | PF00047 PF07714 | 7.4 | IC50 | BindingDB |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 7.1 | IC50 | BindingDB |
| Q9Y2K2 | SIK3 | Homo sapiens | Human | PF00069 PF23312 | 6.6 | IC50 | BindingDB |