Molecule Details
InChIKeyQAJPIJHWTGPUNZ-UHFFFAOYSA-N
Compound Name5-(2-aminopyrimidin-4-yl)-2-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide
Canonical SMILESNC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)37
Pfam Stratification Cross-Family
Avg pChEMBL7.02
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (37)
Target Gene Organism Category Pfam pChEMBL Type Source
O00311 CDC7 Homo sapiens Human PF00069 9.4 Ki ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 8.2 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 7.9 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 7.8 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.6 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 7.6 Ki ChEMBL
P49336 CDK8 Homo sapiens Human PF00069 7.5 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9Y6M4 CSNK1G3 Homo sapiens Human PF12605 PF00069 7.5 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 7.4 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 7.3 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.2 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.1 Ki ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 7.1 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 7.0 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.8 Ki ChEMBL
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 6.8 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.8 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q05655 PRKCD Homo sapiens Human PF00130 PF21494 PF00069 PF00433 6.4 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q13976 PRKG1 Homo sapiens Human PF00027 PF16808 PF00069 6.3 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.3 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.1 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.1 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL