Molecule Details
InChIKeyPZRHRDRVRGEVNW-UHFFFAOYSA-N
Compound NameMilrinone
Canonical SMILESCc1[nH]c(=O)c(C#N)cc1-c1ccncc1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)4
Pfam Stratification Cross-Family
Avg pChEMBL6.32
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00235
Drug NameMilrinone
CAS Number78415-72-2
Groups approved investigational
ATC Codes C01CE02
DescriptionHeart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and me...

Categories: Amines Aminopyridines Cardiac Stimulants Excl. Cardiac Glycosides Cardiac Therapy Cardiotonic Agents Cardiovascular Agents Compounds used in a research, industrial, or household setting Drugs that are Mainly Renally Excreted Enzyme Inhibitors Hematologic Agents Phosphodiesterase 3 Inhibitors Phosphodiesterase Inhibitors Protective Agents Pyridines Vasodilating Agents
Cross-references: BindingDB: 15296 ChEBI: 50693 CHEMBL189 ChemSpider: 4052 Drugs Product Database (DPD): 1216 C07224 D00417 PDB: MIL PharmGKB: PA164749171 PubChem:4197 PubChem:46507838 RxCUI: 52769 Therapeutic Targets Database: DAP000150 Wikipedia: Milrinone ZINC: ZINC000009224016
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13370 PDE3B Homo sapiens Human PF00233 6.4 IC50 ChEMBL;BindingDB
Q14432 PDE3A Homo sapiens Human PF00233 6.4 IC50 ChEMBL;BindingDB
O76074 PDE5A Homo sapiens Human PF01590 PF00233 6.1 IC50 ChEMBL;BindingDB
P23219 PTGS1 Homo sapiens Human PF03098 Clinical TTD_MultiTarget TTD_MultiTarget
DrugBank Target Actions (1)
Target Gene Target Name Action Type
Q14432 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A inhibitor targets