InChIKey	PZFAZQUREQIODZ-LJQANCHMSA-N
Compound Name	(2R)-2-((4-(((3,4-Dihydro-2H-pyrano(2,3-c)pyridin-6-yl)methyl)amino)-1-piperidinyl)methyl)-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione
Canonical SMILES	O=c1ccc2ncc(=O)n3c2n1C[C@H]3CN1CCC(NCc2cc3c(cn2)OCCC3)CC1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Cross-Family
Avg pChEMBL	6.57
Source	ChEMBL

DrugBank ID	DB12134
Drug Name	Gepotidacin
CAS Number	1075236-89-3
Groups	approved investigational
ATC Codes	J01XX13
Description	Gepotidacin is a first-in-class triazaacenaphthylene antibacterial targeting bacterial DNA gyrase and topoisomerase IV.[L52685] Its target is similar to that of fluoroquinolone antibacterials - e.g. [ciprofloxacin] - while being structurally and pharmacologically distinct.[A273755] By inhibiting two...

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Categories: Antibacterials for Systemic Use Antiinfectives for Systemic Use BCRP/ABCG2 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring MATE 1 Inhibitors MATE 2 Inhibitors MATE inhibitors Naphthalenes Topoisomerase Inhibitors Triazaacenaphthylene Bacterial Type II Topoisomerase Inhibitor

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Cross-references: BindingDB: 50050549 CHEMBL3317856 ChemSpider: 34982930 PDB: JHN PubChem:25101874 PubChem:347828432 RxCUI: 2709212 Wikipedia: Gepotidacin