InChIKey	PYGWGZALEOIKDF-UHFFFAOYSA-N
Compound Name	Etravirine
Canonical SMILES	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	6.99
Source	BindingDB;ChEMBL

DrugBank ID	DB06414
Drug Name	Etravirine
CAS Number	269055-15-4
Groups	approved investigational
ATC Codes	J05AG04
Description	Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the ...

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Categories: Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Direct Acting Antivirals Enzyme Inhibitors Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor Non-Nucleoside Reverse Transcriptase Inhibitors Nonnucleoside Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors P-glycoprotein inhibitors Reverse Transcriptase Inhibitors

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Cross-references: BindingDB: 50103642 ChEBI: 63589 CHEMBL308954 ChemSpider: 168313 Drugs Product Database (DPD): 20195 D04112 PDB: 65B PharmGKB: PA166014703 PubChem:193962 PubChem:175427070 RxCUI: 475969 Wikipedia: Etravirine ZINC: ZINC000000602632