Molecule Details
| InChIKey | PXXWCCCMEWRBCG-SFHVURJKSA-N |
|---|---|
| Compound Name | 3-(3-aminopropyl)-5-chloro-2-[(S)-[(6-chloropyrido[3,2-d]pyrimidin-4-yl)amino]-cyclopropylmethyl]quinazolin-4-one |
| Canonical SMILES | NCCCn1c([C@@H](Nc2ncnc3ccc(Cl)nc23)C2CC2)nc2cccc(Cl)c2c1=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.62 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O00329 | PIK3CD | Homo sapiens | Human | PF00454 PF00792 PF02192 PF00794 PF00613 | 8.4 | IC50 | ChEMBL;BindingDB |
| O00459 | PIK3R2 | Homo sapiens | Human | PF16454 PF00620 PF00017 | 8.4 | IC50 | ChEMBL;BindingDB |
| P48736 | PIK3CG | Homo sapiens | Human | PF00454 PF00792 PF00794 PF00613 PF19710 | 6.0 | IC50 | ChEMBL;BindingDB |