Molecule Details
| InChIKey | PUXBGTOOZJQSKH-UHFFFAOYSA-N |
|---|---|
| Compound Name | Carprofen |
| Canonical SMILES | CC(C(=O)O)c1ccc2c(c1)[nH]c1ccc(Cl)cc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.97 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00821 |
|---|---|
| Drug Name | Carprofen |
| CAS Number | 53716-49-7 |
| Groups | approved vet_approved withdrawn |
| ATC Codes | nan |
| Description | Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majorit... |
Categories: Agents causing hyperkalemia Agents that produce hypertension Analgesics Analgesics, Non-Narcotic Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Antirheumatic Agents Dermatologicals Heterocyclic Compounds, Fused-Ring Indoles Nephrotoxic agents OAT1/SLC22A6 inhibitors Peripheral Nervous System Agents Photosensitizing Agents Radiation-Sensitizing Agents Selective Cyclooxygenase 2 Inhibitors (NSAIDs) Sensory System Agents
Cross-references: BindingDB: 50097346 ChEBI: 364453 CHEMBL1316 ChemSpider: 2483 Drugs Product Database (DPD): 11859 C18364 PharmGKB: PA164781361 PubChem:2581 PubChem:46505357 RxCUI: 20343 Therapeutic Targets Database: DAP000975 Wikipedia: Carprofen
Target Activities (3)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P23219 | PTGS1 | Homo sapiens | Human | PF03098 | 7.7 | IC50 | ChEMBL;BindingDB |
| P35354 | PTGS2 | Homo sapiens | Human | PF03098 | 7.0 | IC50 | ChEMBL;BindingDB |
| P01031 | C5 | Homo sapiens | Human | PF00207 PF07703 PF07677 PF01821 PF21309 PF17790 PF01835 PF17791 PF17789 PF01759 PF07678 | 6.2 | Kd | ChEMBL;BindingDB |