Molecule Details
InChIKeyPUPCRRRSBUYJAD-UHFFFAOYSA-N
Compound Name3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-(3-bromophenyl)urea
Canonical SMILESCOc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)44
Pfam Stratification Cross-Family
Avg pChEMBL6.87
SourceBindingDB;ChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (44)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 8.3 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.0 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.0 IC50 ChEMBL;BindingDB
Q02161 RHD Homo sapiens Human PF00909 8.0 pIC50 TTD_MultiTarget
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.8 Ki ChEMBL
P11511 CYP19A1 Homo sapiens Human PF00067 7.8 IC50 BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.8 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.8 Ki ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 7.8 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 7.7 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 7.6 IC50 ChEMBL;BindingDB
Q05397 PTK2 Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 7.6 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.5 IC50 ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.5 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.1 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.9 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
O75676 RPS6KA4 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 6.8 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.8 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.7 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.6 Ki ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.5 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.5 Ki ChEMBL
P29317 EPHA2 Homo sapiens Human PF14575 PF25599 PF01404 PF00041 PF07714 PF00536 6.4 Ki ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.4 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.3 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.2 Ki ChEMBL
P42679 MATK Homo sapiens Human PF07714 PF00017 PF00018 6.2 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.2 Ki ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.2 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.2 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.2 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.1 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.1 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.0 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.0 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.0 Ki ChEMBL