5,6-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine — MultiTargetDB

Molecule Details

InChIKey	`PTILEOLOGGMFCS-UHFFFAOYSA-N`
Compound Name	5,6-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine
Canonical SMILES	`c1ccc(-c2oc3ncnc(NCCN4CCNCC4)c3c2-c2ccccc2)cc1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	6.92
Source	ChEMBL;BindingDB

2D Structure

2D structure

Activity Profile

DrugBank Annotations

DrugBank ID	DB07297
Drug Name	5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
CAS Number	nan
Groups	experimental
ATC Codes	nan
Description	nan

Cross-references: BindingDB: 17714 ChEBI: 40432 CHEMBL247272 ChemSpider: 21865411 PDB: 979 PubChem:17756743 PubChem:99443768 ZINC: ZINC000023359501

Target Activities (2)

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	7.1	IC50	ChEMBL;BindingDB
Q07912	TNK2	Homo sapiens	Human	PF09027 PF11555 PF07714 PF22931 PF14604	6.7	IC50	ChEMBL;BindingDB

DrugBank Target Actions (1)

Target	Gene	Target Name	Action	Type
P06239	LCK	Tyrosine-protein kinase Lck	binder	targets