Molecule Details
InChIKeyPTGXAUBQBSGPKF-UHFFFAOYSA-N
Compound NameNylidrin
Canonical SMILESCC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Homologous
Avg pChEMBL6.21
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06152
Drug NameNylidrin
CAS Number447-41-6
Groups approved withdrawn
ATC Codes C04AA02 G02CA02
DescriptionNylidrin, also known as _buphenine_ belongs to the category of drugs called _vasodilators_, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients wi...

Categories: 2-Amino-1-Phenylethanol Derivatives Adrenergic Agents Adrenergic Agonists Adrenergic beta-Agonists Agents causing hyperkalemia Agents producing tachycardia Agents that produce hypertension Alcohols Amines Amino Alcohols Antiarrhythmic agents Autonomic Agents Bradycardia-Causing Agents Calcium Channel Blockers Cardiovascular Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Ethylamines Genito Urinary System and Sex Hormones Miscellaneous Vasodilatating Agents Neurotransmitter Agents Peripheral Nervous System Agents Peripheral Vasodilators Phenethylamines Propanolamines Propanols Reproductive Control Agents Sympathomimetics Sympathomimetics, Labour Repressants Tocolytic Agents Vasodilating Agents
Cross-references: BindingDB: 50240096 ChEBI: 91656 CHEMBL114655 ChemSpider: 4407 Drugs Product Database (DPD): 9099 PubChem:4567 PubChem:347827757 RxCUI: 7595 Wikipedia: Nylidrin
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P25100 ADRA1D Homo sapiens Human PF00001 6.2 Kd ChEMBL
P35348 ADRA1A Homo sapiens Human PF00001 6.2 Kd ChEMBL
P35368 ADRA1B Homo sapiens Human PF00001 6.2 Kd ChEMBL
DrugBank Target Actions (5)
Target Gene Target Name Action Type
P21964 COMT Catechol O-methyltransferase inducer enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P48551 P48551 Interferon alpha/beta receptor 2 agonist targets
Q9P0X4 CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I agonist targets
Q9P0X4 CACNA1I Voltage-dependent T-type calcium channel subunit alpha-1I antagonist targets