Molecule Details
| InChIKey | PTGXAUBQBSGPKF-UHFFFAOYSA-N |
|---|---|
| Compound Name | Nylidrin |
| Canonical SMILES | CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.21 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06152 |
|---|---|
| Drug Name | Nylidrin |
| CAS Number | 447-41-6 |
| Groups | approved withdrawn |
| ATC Codes | C04AA02 G02CA02 |
| Description | Nylidrin, also known as _buphenine_ belongs to the category of drugs called _vasodilators_, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients wi... |
Categories: 2-Amino-1-Phenylethanol Derivatives Adrenergic Agents Adrenergic Agonists Adrenergic beta-Agonists Agents causing hyperkalemia Agents producing tachycardia Agents that produce hypertension Alcohols Amines Amino Alcohols Antiarrhythmic agents Autonomic Agents Bradycardia-Causing Agents Calcium Channel Blockers Cardiovascular Agents Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Ethylamines Genito Urinary System and Sex Hormones Miscellaneous Vasodilatating Agents Neurotransmitter Agents Peripheral Nervous System Agents Peripheral Vasodilators Phenethylamines Propanolamines Propanols Reproductive Control Agents Sympathomimetics Sympathomimetics, Labour Repressants Tocolytic Agents Vasodilating Agents
Cross-references: BindingDB: 50240096 ChEBI: 91656 CHEMBL114655 ChemSpider: 4407 Drugs Product Database (DPD): 9099 PubChem:4567 PubChem:347827757 RxCUI: 7595 Wikipedia: Nylidrin
Target Activities (3)
DrugBank Target Actions (5)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P21964 | COMT | Catechol O-methyltransferase | inducer | enzymes |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P48551 | P48551 | Interferon alpha/beta receptor 2 | agonist | targets |
| Q9P0X4 | CACNA1I | Voltage-dependent T-type calcium channel subunit alpha-1I | agonist | targets |
| Q9P0X4 | CACNA1I | Voltage-dependent T-type calcium channel subunit alpha-1I | antagonist | targets |