Molecule Details
| InChIKey | PSTHAQGLUUIJDB-UHFFFAOYSA-N |
|---|---|
| Compound Name | 1-[(2,4-Difluorophenyl)methylideneamino]-3-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]urea |
| Canonical SMILES | COc1cc2c(Oc3ccc(NC(=O)NN=Cc4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.35 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08581 | MET | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 8.8 | IC50 | BindingDB |
| Q04912 | MST1R | Homo sapiens | Human | PF07714 PF01437 PF01403 PF01833 | 7.7 | IC50 | BindingDB |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 6.4 | IC50 | BindingDB |
| P16234 | PDGFRA | Homo sapiens | Human | PF07679 PF25305 PF07714 | 6.4 | IC50 | BindingDB |