Molecule Details
| InChIKey | PSOBPHXKKHPWMU-UHFFFAOYSA-N |
|---|---|
| Compound Name | 2-{5-[(4-Chloro-2-Methylphenyl)methoxy]-1h-Pyrazol-1-Yl}pyridine-4-Carboxylic Acid |
| Canonical SMILES | Cc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 10 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.96 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (10)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q9UGL1 | KDM5B | Homo sapiens | Human | PF01388 PF02373 PF02375 PF21323 PF00628 PF08429 PF02928 | 8.7 | IC50 | ChEMBL;BindingDB |
| P29375 | KDM5A | Homo sapiens | Human | PF01388 PF02373 PF02375 PF21323 PF00628 PF08429 PF02928 | 7.9 | IC50 | ChEMBL;BindingDB |
| O75164 | KDM4A | Homo sapiens | Human | PF02373 PF02375 PF13831 PF18104 PF13832 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q9H3R0 | KDM4C | Homo sapiens | Human | PF02373 PF02375 PF13831 PF18104 PF13832 | 7.0 | IC50 | ChEMBL;BindingDB |
| Q6B0I6 | KDM4D | Homo sapiens | Human | PF02373 PF02375 | 7.0 | IC50 | ChEMBL;BindingDB |
| B2RXH2 | KDM4E | Homo sapiens | Human | PF02373 PF02375 | 6.8 | IC50 | ChEMBL;BindingDB |
| O94953 | KDM4B | Homo sapiens | Human | PF02373 PF02375 PF13831 PF18104 PF13832 | 6.8 | IC50 | ChEMBL;BindingDB |
| Q8NHM5 | KDM2B | Homo sapiens | Human | PF13621 PF25372 PF12937 PF17811 PF16866 PF02008 | 6.3 | IC50 | ChEMBL;BindingDB |
| P41229 | KDM5C | Homo sapiens | Human | PF01388 PF02373 PF02375 PF21323 PF00628 PF08429 PF02928 | 6.1 | IC50 | BindingDB |
| Q9Y2K7 | KDM2A | Homo sapiens | Human | PF12937 PF17811 PF16866 PF02008 | 6.1 | IC50 | ChEMBL;BindingDB |