InChIKey	PSGAAPLEWMOORI-PEINSRQWSA-N
Compound Name	Medroxyprogesterone Acetate
Canonical SMILES	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	11
Pfam Stratification	Cross-Family
Avg pChEMBL	6.81
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00603
Drug Name	Medroxyprogesterone acetate
CAS Number	71-58-9
Groups	approved investigational
ATC Codes	G03AA08 G03DA02 G03FB06 G03FA12 L02AB02 G03AA17 G03AC06
Description	Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.[A14848] MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulv...

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Categories: Adrenal Cortex Hormones Antineoplastic Agents Antineoplastic Agents, Hormonal Antineoplastic and Immunomodulating Agents Combination Contraceptives (with Estrogen and derivatives) Contraceptive Agents, Female Contraceptive Agents, Hormonal Contraceptive Agents, Male Contraceptives, Oral Contraceptives, Oral, Hormonal Contraceptives, Oral, Synthetic Corpus Luteum Hormones Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Endocrine Therapy Fused-Ring Compounds Genito Urinary System and Sex Hormones Gonadal Hormones Gonadal Steroid Hormones Hormonal Contraceptives for Systemic Use Hormones Hormones and Related Agents Hormones, Hormone Substitutes, and Hormone Antagonists Hydroxyprogesterones Hyperglycemia-Associated Agents P-glycoprotein inhibitors Pregnanes Pregnen (4) Derivatives Pregnenediones Pregnenes Progesterone Congeners Progesterone and Derivatives Progestin Contraceptives Progestins Progestogens and Estrogens, Sequential Preparations Reproductive Control Agents Sex Hormones and Modulators of the Genital System Steroids

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Cross-references: BindingDB: 50067678 ChEBI: 6716 CHEMBL717 ChemSpider: 6043 Drugs Product Database (DPD): 7538 Guide to Pharmacology: 2879 IUPHAR: 2879 C08150 D00951 PharmGKB: PA450344 PubChem:6279 PubChem:46508895 RxCUI: 1000112 Therapeutic Targets Database: DAP001211 Wikipedia: Medroxyprogesterone ZINC: ZINC000005029557