Molecule Details
InChIKeyPROGKLMIRQVLRO-UHFFFAOYSA-N
Compound NameFlt3/chk1-IN-2
Canonical SMILESCS(=O)(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(NCCCN)n3)ccc2C1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)12
Pfam Stratification Cross-Family
Avg pChEMBL6.34
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (12)
Target Gene Organism Category Pfam pChEMBL Type Source
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.7 IC50 ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 7.6 IC50 ChEMBL
O75582 RPS6KA5 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
O75676 RPS6KA4 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.1 IC50 ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
Q15349 RPS6KA2 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
Q15418 RPS6KA1 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
Q9UBS0 RPS6KB2 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
Q9UK32 RPS6KA6 Homo sapiens Human PF00069 PF00433 6.1 IC50 ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.1 IC50 ChEMBL