Molecule Details
InChIKeyPRIGRJPRGZCFAS-UHFFFAOYSA-N
Compound NameRP107
Canonical SMILESCCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL6.67
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB07364
Drug Name6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 7377 CHEMBL75680 ChemSpider: 20120246 PDB: ALH PubChem:5326843 PubChem:99443835 ZINC: ZINC000002540737
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
P06493 CDK1 Homo sapiens Human PF00069 6.9 pIC50 TTD_MultiTarget
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.9 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.9 pIC50 TTD_MultiTarget
P78396 CCNA1 Homo sapiens Human PF02984 PF00134 PF16500 6.9 IC50 ChEMBL
O95067 CCNB2 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
Q8WWL7 CCNB3 Homo sapiens Human PF02984 PF00134 6.8 IC50 ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
Q15078 CDK5R1 Homo sapiens Human PF03261 6.7 IC50 ChEMBL;BindingDB
O96020 CCNE2 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P24864 CCNE1 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.2 IC50 ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
Q00535 CDK5 Cyclin-dependent kinase 5 binder targets
Q15078 CDK5R1 Cyclin-dependent kinase 5 activator 1 binder targets
P06493 CDK1 Cyclin-dependent kinase 1 inhibitor targets
P24941 CDK2 Cyclin-dependent kinase 2 inhibitor targets