Molecule Details
InChIKeyPPTYJKAXVCCBDU-UHFFFAOYSA-N
Compound NameFlunitrazepam
Canonical SMILESCN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL8.55
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01544
Drug NameFlunitrazepam
CAS Number1622-62-4
Groups approved illicit
ATC Codes N05CD03
DescriptionFlunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of thi...

Categories: Anti-Anxiety Agents Benzazepines Benzodiazepine hypnotics and sedatives Benzodiazepines and benzodiazepine derivatives Benzodiazepinones Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (strength unknown) Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates GABA Agents GABA Modulators Heterocyclic Compounds, Fused-Ring Hypnotics and Sedatives Muscle Relaxants Muscle Relaxants, Centrally Acting Agents Nervous System Neurotransmitter Agents Psycholeptics Psychotropic Drugs Tranquilizing Agents UGT1A1 Inhibitors UGT1A3 Inhibitors UGT2B7 Inhibitors
Cross-references: BindingDB: 25878 ChEBI: 31622 CHEMBL13280 ChemSpider: 3263 D01230 PharmGKB: PA164781320 PubChem:3380 PubChem:46504553 RxCUI: 4460 Therapeutic Targets Database: DAP000931 Wikipedia: Flunitrazepam ZINC: ZINC000003812994
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P31644 GABRA5 Homo sapiens Human PF02931 PF02932 8.7 Ki ChEMBL;BindingDB
P28472 GABRB3 Homo sapiens Human PF02931 PF02932 8.6 Ki ChEMBL
P18507 GABRG2 Homo sapiens Human PF02931 PF02932 8.6 Ki ChEMBL
P47869 GABRA2 Homo sapiens Human PF02931 PF02932 8.6 Ki ChEMBL;BindingDB
P47870 GABRB2 Homo sapiens Human PF02931 PF02932 8.6 Ki ChEMBL
P14867 GABRA1 Homo sapiens Human PF02931 PF02932 8.4 Ki ChEMBL;BindingDB
P34903 GABRA3 Homo sapiens Human PF02931 PF02932 8.3 Ki ChEMBL;BindingDB
DrugBank Target Actions (12)
Target Gene Target Name Action Type
P05181 CYP2E1 Cytochrome P450 2E1 inhibitor enzymes
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 inhibitor enzymes
P22309 UGT1A1 UDP-glucuronosyltransferase 1A1 inhibitor enzymes
P35503 P35503 UDP-glucuronosyltransferase 1A3 inhibitor enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P11509 CYP2A6 Cytochrome P450 2A6 substrate enzymes
P11712 CYP2C9 Cytochrome P450 2C9 substrate enzymes
P20813 CYP2B6 Cytochrome P450 2B6 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
P30536 TSPO Translocator protein agonist targets
P14867 GABRA1 GABA(A) Receptor Benzodiazepine Binding Site ligand targets
P14867 GABRA1 GABA(A) Receptor positive allosteric modulator targets