InChIKey	PMATZTZNYRCHOR-CGLBZJNRSA-N
Compound Name	Cyclosporin A
Canonical SMILES	C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	20
Pfam Stratification	Cross-Family
Avg pChEMBL	6.83
Source	BindingDB;ChEMBL

DrugBank ID	DB00091
Drug Name	Cyclosporine
CAS Number	59865-13-3
Groups	approved investigational vet_approved
ATC Codes	L04AD01 S01XA18
Description	Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_.[A174049] Initially manufactured by Sandoz and approved for use by the ...

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Categories: Agents Causing Muscle Toxicity Agents causing hyperkalemia Agents that produce hypertension Agents that produce neuromuscular block (indirect) Agents that reduce seizure threshold Amino Acids, Peptides, and Proteins Anti-Inflammatory Agents Antirheumatic Agents BCRP/ABCG2 Inhibitors BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates BSEP/ABCB11 Substrates with a Narrow Therapeutic Index Calcineurin Inhibitor Immunosuppressant Calcineurin Inhibitors Cyclosporins Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Immunologic Factors Immunosuppressive Agents NTCP Inhibitors Narrow Therapeutic Index Drugs Nephrotoxic agents Neurotoxic agents OAT1/SLC22A6 Substrates OAT1/SLC22A6 inhibitors OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inhibitors Ophthalmologicals P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Peptides Peptides, Cyclic

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Cross-references: BindingDB: 50022815 ChEBI: 4031 CHEMBL160 ChemSpider: 4447449 Drugs Product Database (DPD): 11396 C05086 D00184 PharmGKB: PA449167 PubChem:5284373 PubChem:46508198 RxCUI: 3008 Therapeutic Targets Database: DNC001177 Wikipedia: Ciclosporin