1-[(2R,3R)-3-[[6-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanone

InChIKey	`PLZWVXKEQYGKTJ-AUSIDOKSSA-N`
Compound Name	1-[(2R,3R)-3-[[6-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl]amino]-2-(4-fluorophenyl)pyrrolidin-1-yl]ethanone
Canonical SMILES	`CC(=O)N1CC[C@@H](Nc2cncc(C(=O)c3cn(C(C)C)c4ncnc(N)c34)n2)[C@H]1c1ccc(F)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	7
Pfam Stratification	Cross-Family
Avg pChEMBL	6.46
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
O15530	PDPK1	Homo sapiens	Human	PF14593 PF00069	7.1	IC50	ChEMBL;BindingDB
P49841	GSK3B	Homo sapiens	Human	PF00069	6.5	IC50	ChEMBL;BindingDB
P31749	AKT1	Homo sapiens	Human	PF00169 PF00069 PF00433	6.4	pIC50	TTD_MultiTarget
P42345	MTOR	Homo sapiens	Human	PF02259 PF02260 PF08771 PF23593 PF11865 PF00454	6.4	pIC50	TTD_MultiTarget
O14965	AURKA	Homo sapiens	Human	PF00069	6.3	IC50	ChEMBL;BindingDB
Q9P0L2	MARK1	Homo sapiens	Human	PF02149 PF00069 PF00627	6.2	IC50	ChEMBL;BindingDB
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.2	IC50	ChEMBL;BindingDB