Molecule Details
InChIKeyPKKNCEXEVUFFFI-UHFFFAOYSA-N
Compound NameNevanimibe
Canonical SMILESCC(C)c1cccc(C(C)C)c1NC(=O)NCC1(c2ccc(N(C)C)cc2)CCCC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.07
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB16254
Drug NameNevanimibe
CAS Number133825-80-6
Groups investigational
ATC Codes nan
DescriptionNevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome).

Categories: Amides Benzene Derivatives
Cross-references: BindingDB: 50041735 CHEMBL46423 ChemSpider: 116346 PDB: ROV
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P35610 SOAT1 Homo sapiens Human PF03062 8.1 IC50 ChEMBL
P24752 ACAT1 Homo sapiens Human PF02803 PF00108 6.7 IC50 ChEMBL
O75908 SOAT2 Homo sapiens Human PF03062 6.4 IC50 ChEMBL
DrugBank Target Actions (2)
Target Gene Target Name Action Type
O75908 SOAT2 Sterol O-acyltransferase 2 modulator targets
P35610 SOAT1 Sterol O-acyltransferase 1 modulator targets