Molecule Details
| InChIKey | PKGAXGNVVMHTJZ-UHFFFAOYSA-N |
|---|---|
| Compound Name | US10077269, Example 61 |
| Canonical SMILES | O=C(c1nc2cccnn2c1-c1ccc(Cl)cc1)N1CC(F)(F)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.85 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q08493 | PDE4C | Homo sapiens | Human | PF18100 PF00233 | 6.9 | IC50 | ChEMBL;BindingDB |
| Q08499 | PDE4D | Homo sapiens | Human | PF18100 PF00233 | 6.9 | IC50 | ChEMBL;BindingDB |
| P27815 | PDE4A | Homo sapiens | Human | PF18100 PF00233 | 6.8 | IC50 | ChEMBL;BindingDB |
| Q07343 | PDE4B | Homo sapiens | Human | PF18100 PF00233 | 6.7 | IC50 | ChEMBL;BindingDB |