InChIKey	PHWXUGHIIBDVKD-UHFFFAOYSA-N
Compound Name	Sitaxentan
Canonical SMILES	Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Homologous
Avg pChEMBL	8.43
Source	BindingDB;ChEMBL

DrugBank ID	DB06268
Drug Name	Sitaxentan
CAS Number	184036-34-8
Groups	approved withdrawn
ATC Codes	C02KX03
Description	Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity.

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Categories: Antihypertensive Agents Antihypertensives for Pulmonary Arterial Hypertension Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Endothelin Receptor Antagonists Sulfur Compounds

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Cross-references: BindingDB: 50058126 ChEBI: 135736 CHEMBL282724 ChemSpider: 187436 Drugs Product Database (DPD): 20136 Guide to Pharmacology: 3950 IUPHAR: 3950 D07171 PharmGKB: PA165958361 PubChem:216235 PubChem:99443241 Wikipedia: Sitaxentan ZINC: ZINC000001481831