Molecule Details
| InChIKey | PHEZJEYUWHETKO-UHFFFAOYSA-N |
|---|---|
| Compound Name | Brequinar |
| Canonical SMILES | Cc1c(-c2ccc(-c3ccccc3F)cc2)nc2ccc(F)cc2c1C(=O)O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 3 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.66 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB03523 |
|---|---|
| Drug Name | Brequinar |
| CAS Number | 96187-53-0 |
| Groups | investigational |
| ATC Codes | nan |
| Description | nan |
Categories: Antineoplastic Agents Benzene Derivatives Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Immunologic Factors Immunosuppressive Agents Oxidoreductases Quinolines
Cross-references: BindingDB: 15339 ChEBI: 177387 CHEMBL38434 ChemSpider: 51422 PDB: BRF PubChem:57030 PubChem:46504783 Wikipedia: Brequinar ZINC: ZINC000001587011
Target Activities (3)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q02127 | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial | modulator | targets |