Molecule Details
InChIKeyPGKXDIMONUAMFR-AREMUKBSSA-N
Compound NameSaredutant
Canonical SMILESCC(=O)NC1(c2ccccc2)CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL7.75
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB06660
Drug NameSaredutant
CAS Number142001-63-6
Groups investigational
ATC Codes nan
DescriptionSaredutant (SR 48968) is a neurokinin-2 antagonist drug being developed as an antidepressant and anxiolytic by Sanofi-Aventis.
Categories: Acids, Carbocyclic Amides Antidepressive Agents Benzene Derivatives Benzoates Central Nervous System Depressants Receptors, Neurokinin-2, antagonists & inhibitors
Cross-references: BindingDB: 50071484 CHEMBL308148 ChemSpider: 94726 Wikipedia: Saredutant ZINC: ZINC000003927605
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
P21452 TACR2 Homo sapiens Human PF00001 9.3 IC50 ChEMBL;BindingDB
P25103 TACR1 Homo sapiens Human PF00001 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (1)
Target Gene Target Name Action Type
P21452 TACR2 Substance-K receptor antagonist targets