Molecule Details
InChIKeyPGBHMTALBVVCIT-VCIWKGPPSA-N
Compound NameNeomycin
Canonical SMILESNC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)59
Pfam Stratification Cross-Family
Avg pChEMBL7.45
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00452
Drug NameFramycetin
CAS Number119-04-0
Groups approved investigational
ATC Codes D09AA01 R01AX08 S01AA07
DescriptionA component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

Categories: Agents that produce neuromuscular block (indirect) Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Carbohydrates Dermatologicals Glycosides Medicated Dressings Medicated Dressings With Antiinfectives Nasal Preparations Nephrotoxic agents Ophthalmologicals Sensory Organs
Cross-references: BindingDB: 19 ChEBI: 7508 CHEMBL184618 ChemSpider: 8075 Drugs Product Database (DPD): 8626 C01737 D05140 PDB: NMY PharmGKB: PA164743181 PubChem:8378 PubChem:46508892 RxCUI: 4556 Therapeutic Targets Database: DNC001005 Wikipedia: Neomycin ZINC: ZINC000071928291
Target Activities (59)
Target Gene Organism Category Pfam pChEMBL Type Source
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 IC50 BindingDB
Q8NER1 TRPV1 Homo sapiens Human PF00023 PF12796 PF00520 6.4 IC50 ChEMBL
P02358 rpsF Escherichia coli (strain K12) Pathogen PF01250 7.5 IC50 ChEMBL
P02359 rpsG Escherichia coli (strain K12) Pathogen PF00177 7.5 IC50 ChEMBL
P02413 rplO Escherichia coli (strain K12) Pathogen PF00828 7.5 IC50 ChEMBL
P0A7J3 rplJ Escherichia coli (strain K12) Pathogen PF00466 7.5 IC50 ChEMBL
P0A7J7 rplK Escherichia coli (strain K12) Pathogen PF00298 PF03946 7.5 IC50 ChEMBL
P0A7K2 rplL Escherichia coli (strain K12) Pathogen PF00542 PF16320 7.5 IC50 ChEMBL
P0A7K6 rplS Escherichia coli (strain K12) Pathogen PF01245 7.5 IC50 ChEMBL
P0A7L0 rplA Escherichia coli (strain K12) Pathogen PF00687 7.5 IC50 ChEMBL
P0A7L3 rplT Escherichia coli (strain K12) Pathogen PF00453 7.5 IC50 ChEMBL
P0A7L8 rpmA Escherichia coli (strain K12) Pathogen PF01016 7.5 IC50 ChEMBL
P0A7M2 rpmB Escherichia coli (strain K12) Pathogen PF00830 7.5 IC50 ChEMBL
P0A7M6 rpmC Escherichia coli (strain K12) Pathogen PF00831 7.5 IC50 ChEMBL
P0A7M9 rpmE Escherichia coli (strain K12) Pathogen PF01197 7.5 IC50 ChEMBL
P0A7N1 ykgM Escherichia coli (strain K12) Pathogen PF01197 7.5 IC50 ChEMBL
P0A7N4 rpmF Escherichia coli (strain K12) Pathogen PF01783 7.5 IC50 ChEMBL
P0A7N9 rpmG Escherichia coli (strain K12) Pathogen PF00471 7.5 IC50 ChEMBL
P0A7P5 rpmH Escherichia coli (strain K12) Pathogen PF00468 7.5 IC50 ChEMBL
P0A7Q1 rpmI Escherichia coli (strain K12) Pathogen PF01632 7.5 IC50 ChEMBL
P0A7Q6 rpmJ Escherichia coli (strain K12) Pathogen PF00444 7.5 IC50 ChEMBL
P0A7R5 rpsJ Escherichia coli (strain K12) Pathogen PF00338 7.5 IC50 ChEMBL
P0A7R9 rpsK Escherichia coli (strain K12) Pathogen PF00411 7.5 IC50 ChEMBL
P0A7S3 rpsL Escherichia coli (strain K12) Pathogen PF00164 7.5 IC50 ChEMBL
P0A7S9 rpsM Escherichia coli (strain K12) Pathogen PF00416 7.5 IC50 ChEMBL
P0A7T3 rpsP Escherichia coli (strain K12) Pathogen PF00886 7.5 IC50 ChEMBL
P0A7T7 rpsR Escherichia coli (strain K12) Pathogen PF01084 7.5 IC50 ChEMBL
P0A7U3 rpsS Escherichia coli (strain K12) Pathogen PF00203 7.5 IC50 ChEMBL
P0A7U7 rpsT Escherichia coli (strain K12) Pathogen PF01649 7.5 IC50 ChEMBL
P0A7V0 rpsB Escherichia coli (strain K12) Pathogen PF00318 7.5 IC50 ChEMBL
P0A7V3 rpsC Escherichia coli (strain K12) Pathogen PF07650 PF00189 7.5 IC50 ChEMBL
P0A7V8 rpsD Escherichia coli (strain K12) Pathogen PF00163 PF01479 7.5 IC50 ChEMBL
P0A7W1 rpsE Escherichia coli (strain K12) Pathogen PF00333 PF03719 7.5 IC50 ChEMBL
P0A7W7 rpsH Escherichia coli (strain K12) Pathogen PF00410 7.5 IC50 ChEMBL
P0A7X3 rpsI Escherichia coli (strain K12) Pathogen PF00380 7.5 IC50 ChEMBL
P0AA10 rplM Escherichia coli (strain K12) Pathogen PF00572 7.5 IC50 ChEMBL
P0ADY3 rplN Escherichia coli (strain K12) Pathogen PF00238 7.5 IC50 ChEMBL
P0ADY7 rplP Escherichia coli (strain K12) Pathogen PF00252 7.5 IC50 ChEMBL
P0ADZ0 rplW Escherichia coli (strain K12) Pathogen PF00276 7.5 IC50 ChEMBL
P0ADZ4 rpsO Escherichia coli (strain K12) Pathogen PF00312 7.5 IC50 ChEMBL
P0AG44 rplQ Escherichia coli (strain K12) Pathogen PF01196 7.5 IC50 ChEMBL
P0AG48 rplU Escherichia coli (strain K12) Pathogen PF00829 7.5 IC50 ChEMBL
P0AG51 rpmD Escherichia coli (strain K12) Pathogen PF00327 7.5 IC50 ChEMBL
P0AG55 rplF Escherichia coli (strain K12) Pathogen PF00347 7.5 IC50 ChEMBL
P0AG59 rpsN Escherichia coli (strain K12) Pathogen PF00253 7.5 IC50 ChEMBL
P0AG63 rpsQ Escherichia coli (strain K12) Pathogen PF00366 7.5 IC50 ChEMBL
P0AG67 rpsA Escherichia coli (strain K12) Pathogen PF00575 7.5 IC50 ChEMBL
P0C018 rplR Escherichia coli (strain K12) Pathogen PF00861 7.5 IC50 ChEMBL
P60422 rplB Escherichia coli (strain K12) Pathogen PF03947 PF00181 7.5 IC50 ChEMBL
P60438 rplC Escherichia coli (strain K12) Pathogen PF00297 7.5 IC50 ChEMBL
P60624 rplX Escherichia coli (strain K12) Pathogen PF00467 PF17136 7.5 IC50 ChEMBL
P60723 rplD Escherichia coli (strain K12) Pathogen PF00573 7.5 IC50 ChEMBL
P61175 rplV Escherichia coli (strain K12) Pathogen PF00237 7.5 IC50 ChEMBL
P62399 rplE Escherichia coli (strain K12) Pathogen PF00281 PF00673 7.5 IC50 ChEMBL
P68679 rpsU Escherichia coli (strain K12) Pathogen PF01165 7.5 IC50 ChEMBL
P68919 rplY Escherichia coli (strain K12) Pathogen PF01386 7.5 IC50 ChEMBL
Q2EEQ2 ykgO Escherichia coli (strain K12) Pathogen PF00444 7.5 IC50 ChEMBL
Q77Y21 rev Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) Pathogen PF00424 6.8 Kd ChEMBL
P15917 lef Bacillus anthracis Pathogen PF09156 PF07737 6.3 Ki ChEMBL;BindingDB
DrugBank Target Actions (2)
Target Gene Target Name Action Type
P61073 CXCR4 C-X-C chemokine receptor type 4 antagonist targets
P0A7S3 rpsL Small ribosomal subunit protein uS12 inhibitor targets