N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide

InChIKey	`PFTXFNSHFZLJNT-UHFFFAOYSA-N`
Compound Name	N-cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]benzamide
Canonical SMILES	`COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	17
Pfam Stratification	Cross-Family
Avg pChEMBL	7.0
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	9.2	IC50	ChEMBL
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	9.2	IC50	ChEMBL
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	8.7	IC50	ChEMBL
O43353	RIPK2	Homo sapiens	Human	PF00619 PF07714	7.7	IC50	ChEMBL
Q08345	DDR1	Homo sapiens	Human	PF21114 PF00754 PF07714	7.2	IC50	ChEMBL
P53667	LIMK1	Homo sapiens	Human	PF00412 PF00595 PF07714	7.2	IC50	ChEMBL
Q9NYL2	MAP3K20	Homo sapiens	Human	PF07714 PF07647	7.0	IC50	ChEMBL
P07948	LYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.6	IC50	ChEMBL
P00519	ABL1	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.5	IC50	ChEMBL
P06239	LCK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	IC50	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.3	IC50	ChEMBL
P42684	ABL2	Homo sapiens	Human	PF08919 PF07714 PF00017 PF00018	6.3	IC50	ChEMBL
P07947	YES1	Homo sapiens	Human	PF07714 PF00017 PF00018	6.2	IC50	ChEMBL
P07333	CSF1R	Homo sapiens	Human	PF00047 PF25305 PF07714	6.2	IC50	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.1	IC50	ChEMBL
P27037	ACVR2A	Homo sapiens	Human	PF01064 PF00069	6.1	IC50	ChEMBL
Q04771	ACVR1	Homo sapiens	Human	PF01064 PF07714 PF08515	6.0	IC50	ChEMBL