Molecule Details
| InChIKey | PFBFUNWWEQQNQB-GQCTYLIASA-N |
|---|---|
| Compound Name | (12E)-17-amino-N-propan-2-yl-15-oxa-2,6,8,21-tetrazatricyclo[14.3.1.13,7]henicosa-1(20),3(21),4,6,12,16,18-heptaene-4-carboxamide |
| Canonical SMILES | CC(C)NC(=O)c1cnc2nc1Nc1ccc(N)c(c1)OC/C=C/CCCN2 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.89 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q12866 | MERTK | Homo sapiens | Human | PF00041 PF00047 PF13927 PF07714 | 8.0 | IC50 | ChEMBL |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 6.8 | IC50 | ChEMBL |
| P30530 | AXL | Homo sapiens | Human | PF00041 PF13927 PF07714 | 6.5 | IC50 | ChEMBL |
| Q06418 | TYRO3 | Homo sapiens | Human | PF00041 PF07679 PF07714 | 6.3 | IC50 | ChEMBL |