Molecule Details
InChIKeyPCSKFQHKWWNIKM-UHFFFAOYSA-N
Compound NameN-[4-(1,3a,4,5,7,7a-hexahydropyrazolo[3,4-c]pyridin-6-ylmethyl)-3-chlorophenyl]-3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
Canonical SMILESCc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL7.33
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 8.7 IC50 ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.2 IC50 ChEMBL;BindingDB
P54753 EPHB3 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 7.3 IC50 ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 7.0 IC50 ChEMBL;BindingDB
P29323 EPHB2 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 7.0 IC50 ChEMBL;BindingDB
P54760 EPHB4 Homo sapiens Human PF14575 PF25599 PF01404 PF07699 PF00041 PF07714 PF00536 6.9 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.2 IC50 ChEMBL;BindingDB