Molecule Details
InChIKeyPCQMERRARZKTPW-UHFFFAOYSA-N
Compound Name3-(3-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide
Canonical SMILESNC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)68
Pfam Stratification Cross-Family
Avg pChEMBL6.71
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (68)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.8 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.7 Ki ChEMBL
Q13627 DYRK1A Homo sapiens Human PF00069 7.6 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.5 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 7.5 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.4 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 7.3 Ki ChEMBL
Q13555 CAMK2G Homo sapiens Human PF08332 PF00069 7.3 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.2 Ki ChEMBL
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.2 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 7.2 Ki ChEMBL
P43405 SYK Homo sapiens Human PF07714 PF00017 7.1 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 7.1 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 7.1 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.1 Ki ChEMBL
P16591 FER Homo sapiens Human PF00611 PF07714 PF00017 7.0 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 7.0 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.9 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.9 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.9 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.9 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.9 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q08881 ITK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 6.8 Ki ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.7 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 6.7 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.6 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.6 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.6 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.5 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.5 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.4 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 Ki ChEMBL
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.4 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.4 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q13554 CAMK2B Homo sapiens Human PF08332 PF00069 6.4 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.4 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 6.4 Ki ChEMBL
P07332 FES Homo sapiens Human PF00611 PF07714 PF00017 6.3 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P51817 PRKX Homo sapiens Human PF00069 6.3 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.3 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.3 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 6.2 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 6.2 Ki ChEMBL
O96013 PAK4 Homo sapiens Human PF00786 PF00069 6.2 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.2 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.1 Ki ChEMBL
P08922 ROS1 Homo sapiens Human PF00041 PF07714 6.1 Ki ChEMBL
Q5VT25 CDC42BPA Homo sapiens Human PF00130 PF00780 PF08826 PF15796 PF25346 PF00069 PF00433 6.1 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.1 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.0 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL