Molecule Details
| InChIKey | PBACTZXZNFJQGT-GHXNOFRVSA-N |
|---|---|
| Compound Name | (Z)-2-cyano-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]prop-2-enamide |
| Canonical SMILES | N#C/C(=C/c1cccc(-c2ncnc3[nH]ccc23)c1)C(N)=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.41 |
| Source | ChEMBL |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P52333 | JAK3 | Homo sapiens | Human | PF18379 PF18377 PF17887 PF07714 PF21990 | 9.1 | IC50 | ChEMBL |
| Q14680 | MELK | Homo sapiens | Human | PF02149 PF00069 PF21594 | 7.6 | IC50 | ChEMBL |
| P45985 | MAP2K4 | Homo sapiens | Human | PF00069 | 6.5 | IC50 | ChEMBL |
| P51812 | RPS6KA3 | Homo sapiens | Human | PF00069 PF00433 | 6.4 | IC50 | ChEMBL |