Molecule Details
InChIKeyPAZJSJFMUHDSTF-UHFFFAOYSA-N
Compound NameAlprenolol
Canonical SMILESC=CCc1ccccc1OCC(O)CNC(C)C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)4
Pfam Stratification Homologous
Avg pChEMBL7.82
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00866
Drug NameAlprenolol
CAS Number13655-52-2
Groups approved withdrawn
ATC Codes C07AA01
DescriptionOne of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Alprenolol is no longer marketed by AstraZeneca, but may still be available in generic varieties.
Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic beta-Antagonists Agents causing hyperkalemia Alcohols Amines Amino Alcohols Antiarrhythmic agents Antidepressive Agents Antihypertensive Agents Autonomic Agents Beta Blocking Agents, Non-Selective Bradycardia-Causing Agents Cardiovascular Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 Substrates Neurotransmitter Agents Peripheral Nervous System Agents Phenoxypropanolamines Propanolamines Propanols Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Sympatholytics
Cross-references: BindingDB: 25764 ChEBI: 51211 CHEMBL266195 ChemSpider: 2035 D07156 PharmGKB: PA164750541 PubChem:2119 PubChem:46506033 RxCUI: 597 Therapeutic Targets Database: DAP000941 Wikipedia: Alprenolol
Target Activities (4)
Target Gene Organism Category Pfam pChEMBL Type Source
P07550 ADRB2 Homo sapiens Human PF00001 8.9 Kd ChEMBL
P08588 ADRB1 Homo sapiens Human PF00001 8.3 IC50 ChEMBL
P13945 ADRB3 Homo sapiens Human PF00001 7.1 Kd ChEMBL
P08908 HTR1A Homo sapiens Human PF00001 6.9 IC50 ChEMBL
DrugBank Target Actions (5)
Target Gene Target Name Action Type
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P07550 ADRB2 Beta-2 adrenergic receptor antagonist targets
P08588 ADRB1 Beta-1 adrenergic receptor antagonist targets
P08908 HTR1A 5-hydroxytryptamine receptor 1A antagonist targets
P13945 ADRB3 Beta-3 adrenergic receptor antagonist targets