Molecule Details
InChIKeyOZMNMGRHACMSBT-UHFFFAOYSA-N
Compound NameN8 Pyrido[2,3-d]pyrimidin-7-one deriv. 45
Canonical SMILESO=c1ccc2cnc(Nc3ccccc3)nc2n1C1CCCC1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL7.26
SourceChEMBL;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
P11802 CDK4 Homo sapiens Human PF00069 7.9 pIC50 TTD_MultiTarget
P24941 CDK2 Homo sapiens Human PF00069 7.9 pIC50 TTD_MultiTarget
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 7.7 IC50 ChEMBL
P24385 CCND1 Homo sapiens Human PF02984 PF00134 6.7 IC50 ChEMBL
P30279 CCND2 Homo sapiens Human PF02984 PF00134 6.7 IC50 ChEMBL
P30281 CCND3 Homo sapiens Human PF02984 PF00134 6.7 IC50 ChEMBL