Molecule Details
| InChIKey | OZGNYLLQHRPOBR-DHZHZOJOSA-N |
|---|---|
| Compound Name | Naftifine |
| Canonical SMILES | CN(C/C=C/c1ccccc1)Cc1cccc2ccccc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.4 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00735 |
|---|---|
| Drug Name | Naftifine |
| CAS Number | 65472-88-0 |
| Groups | approved |
| ATC Codes | D01AE22 |
| Description | Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum. |
Categories: Alkenes Allyl Compounds Allylamine Antifungal Amines Anti-Infective Agents Antifungal Agents Antifungals for Dermatological Use Antifungals for Topical Use Dermatologicals Hydrocarbons, Acyclic
Cross-references: BindingDB: 50170647 ChEBI: 7451 CHEMBL626 ChemSpider: 43344 Drugs Product Database (DPD): 1186 C08071 PharmGKB: PA164748617 PubChem:73342 PubChem:46504777 RxCUI: 31476 Therapeutic Targets Database: DAP000752 Wikipedia: Naftifine ZINC: ZINC000001530977
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q99720 | SIGMAR1 | Homo sapiens | Human | PF04622 | 6.1 | Ki | ChEMBL;BindingDB |
| O07855 | crtN | Staphylococcus aureus (strain Newman) | Pathogen | PF01593 | 6.5 | IC50 | ChEMBL;BindingDB |
| P32352 | ERG2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Pathogen | PF04622 | 6.5 | Ki | ChEMBL;BindingDB |
| Q92206 | ERG1 | Candida albicans (strain SC5314 / ATCC MYA-2876) | Pathogen | PF08491 | 6.5 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q14534 | SQLE | Squalene monooxygenase | inhibitor | targets |