Molecule Details
InChIKeyOYONTEXKYJZFHA-SSHUPFPWSA-N
Compound Name(3Z)-5-(((2,6-Dichlorophenyl)methyl)sulfonyl)-3-((3,5-dimethyl-4-(((2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one
Canonical SMILESCc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)69
Pfam Stratification Cross-Family
Avg pChEMBL6.53
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (69)
Target Gene Organism Category Pfam pChEMBL Type Source
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 8.1 IC50 ChEMBL;BindingDB
Q96SB4 SRPK1 Homo sapiens Human PF00069 7.4 Kd ChEMBL;BindingDB
Q9H2K8 TAOK3 Homo sapiens Human PF00069 7.4 Kd ChEMBL;BindingDB
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 7.3 Kd ChEMBL;BindingDB
Q8WTQ7 GRK7 Homo sapiens Human PF00069 PF00615 7.2 Kd ChEMBL;BindingDB
Q8N5S9 CAMKK1 Homo sapiens Human PF00069 7.2 Kd ChEMBL;BindingDB
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.2 IC50 ChEMBL;BindingDB
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 7.2 Kd ChEMBL;BindingDB
Q96RR4 CAMKK2 Homo sapiens Human PF00069 7.1 Kd ChEMBL;BindingDB
Q56UN5 MAP3K19 Homo sapiens Human PF00069 7.1 Kd ChEMBL;BindingDB
Q9H422 HIPK3 Homo sapiens Human PF00069 7.1 IC50 ChEMBL;BindingDB
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 7.1 Kd ChEMBL;BindingDB
Q86Z02 HIPK1 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.0 Kd ChEMBL;BindingDB
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.0 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.9 Kd ChEMBL;BindingDB
Q92918 MAP4K1 Homo sapiens Human PF00780 PF00069 6.8 Kd ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.7 Kd ChEMBL;BindingDB
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.7 pIC50 TTD_MultiTarget
P18505 GABRB1 Homo sapiens Human PF02931 PF02932 6.7 pIC50 TTD_MultiTarget
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.6 Kd ChEMBL;BindingDB
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.5 Kd ChEMBL;BindingDB
Q99755 PIP5K1A Homo sapiens Human PF01504 6.5 Kd ChEMBL;BindingDB
O94804 STK10 Homo sapiens Human PF00069 PF12474 6.5 Kd ChEMBL;BindingDB
Q9UQB9 AURKC Homo sapiens Human PF00069 6.5 Kd ChEMBL;BindingDB
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.5 Kd ChEMBL;BindingDB
Q9UKE5 TNIK Homo sapiens Human PF00780 PF00069 6.5 Kd ChEMBL;BindingDB
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 6.5 Kd ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.5 Kd ChEMBL;BindingDB
Q2M2I8 AAK1 Homo sapiens Human PF00069 6.5 Kd ChEMBL;BindingDB
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.5 Kd ChEMBL;BindingDB
P11802 CDK4 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
O14730 RIOK3 Homo sapiens Human PF01163 6.4 Kd ChEMBL;BindingDB
Q9UPZ9 CILK1 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.4 Kd ChEMBL;BindingDB
P49760 CLK2 Homo sapiens Human PF00069 6.4 Kd ChEMBL;BindingDB
P32298 GRK4 Homo sapiens Human PF00069 PF00615 6.4 Kd ChEMBL;BindingDB
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 IC50 ChEMBL;BindingDB
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.4 Kd ChEMBL;BindingDB
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Kd ChEMBL;BindingDB
Q9BRS2 RIOK1 Homo sapiens Human PF01163 6.3 Kd ChEMBL;BindingDB
Q8IVH8 MAP4K3 Homo sapiens Human PF00780 PF00069 6.3 Kd ChEMBL;BindingDB
P78362 SRPK2 Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
Q96Q40 CDK15 Homo sapiens Human PF00069 6.3 Kd ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.3 Kd ChEMBL;BindingDB
P10721 KIT Homo sapiens Human PF00047 PF07714 6.2 Kd ChEMBL;BindingDB
P51955 NEK2 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
O60285 NUAK1 Homo sapiens Human PF00069 6.2 Kd ChEMBL;BindingDB
Q9Y616 IRAK3 Homo sapiens Human PF00531 PF00069 6.2 Kd ChEMBL;BindingDB
Q12852 MAP3K12 Homo sapiens Human PF07714 6.2 Kd ChEMBL;BindingDB
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.2 Kd ChEMBL;BindingDB
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.2 Kd ChEMBL;BindingDB
P49759 CLK1 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.1 Kd ChEMBL;BindingDB
P54646 PRKAA2 Homo sapiens Human PF16579 PF21147 PF00069 6.1 Kd ChEMBL;BindingDB
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 6.1 Kd ChEMBL;BindingDB
Q9BYT3 STK33 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
P49674 CSNK1E Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
Q00537 CDK17 Homo sapiens Human PF00069 6.1 Kd ChEMBL;BindingDB
P20794 MAK Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.0 Kd ChEMBL;BindingDB
Q9H093 NUAK2 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.0 Kd ChEMBL;BindingDB
Q9H1R3 MYLK2 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
P36507 MAP2K2 Homo sapiens Human PF00069 6.0 Kd ChEMBL;BindingDB
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.0 Kd ChEMBL;BindingDB
Q8N568 DCLK2 Homo sapiens Human PF03607 PF00069 6.0 Kd ChEMBL;BindingDB