Molecule Details
InChIKeyOWFLADWRSCINST-UHFFFAOYSA-N
Compound Name2-(2-Quinolin-3-ylpyridin-4-YL)-1,5,6,7-tetrahydro-4H-pyrrolo(3,2-C)pyridin-4-one
Canonical SMILESO=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)30
Pfam Stratification Homologous
Avg pChEMBL6.77
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB08358
Drug Name2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
CAS Numbernan
Groups experimental
ATC Codes nan
Descriptionnan

Cross-references: BindingDB: 30185 CHEMBL226403 ChemSpider: 8564681 PDB: P4O PubChem:10389239 PubChem:99444829 ZINC: ZINC000016052855
Target Activities (30)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13627 DYRK1A Homo sapiens Human PF00069 8.4 Ki ChEMBL
P49137 MAPKAPK2 Homo sapiens Human PF00069 8.1 IC50 ChEMBL;BindingDB
O43293 DAPK3 Homo sapiens Human PF00069 7.6 Ki ChEMBL
Q86V86 PIM3 Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 7.4 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.2 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q9UEE5 STK17A Homo sapiens Human PF00069 7.2 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 7.1 IC50 ChEMBL;BindingDB
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.8 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q16644 MAPKAPK3 Homo sapiens Human PF00069 6.7 IC50 ChEMBL;BindingDB
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 6.6 Ki ChEMBL
Q9HCP0 CSNK1G1 Homo sapiens Human PF12605 PF00069 6.6 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 6.5 Ki ChEMBL
Q9NR20 DYRK4 Homo sapiens Human PF00069 6.5 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q9P1W9 PIM2 Homo sapiens Human PF00069 6.4 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q13557 CAMK2D Homo sapiens Human PF08332 PF00069 6.1 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.0 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 6.0 Ki ChEMBL
DrugBank Target Actions (3)
Target Gene Target Name Action Type
Q16644 MAPKAPK3 MAP kinase-activated protein kinase 3 binder targets
P49137 MAPKAPK2 MAP kinase-activated protein kinase 2 inhibitor targets
Q8IW41 MAPKAPK5 MAP kinase-activated protein kinase 5 inhibitor targets